Abstract
An enantioselective synthesis of the (1'S,2'R)-dimethylheptyl cannabinoid side chain has been developed and employed in the synthesis of 11-hydroxy-(1'S,2'R)-dimethylheptyl-delta 8-THC (3). Pharmacology, in vivo and in vitro, indicate (3) to be one of the most potent traditional cannabinoids known.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Binding, Competitive
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Brain / metabolism
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Cannabinoids / pharmacokinetics
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Cell Membrane / metabolism
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Cyclohexanols / pharmacokinetics
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Dronabinol / analogs & derivatives*
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Dronabinol / chemistry
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Indicators and Reagents
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Kinetics
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Mice
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Molecular Structure
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Receptors, Cannabinoid
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Receptors, Drug / drug effects
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Receptors, Drug / metabolism*
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Cannabinoids
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Cyclohexanols
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Indicators and Reagents
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Receptors, Cannabinoid
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Receptors, Drug
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Dronabinol
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3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol